实验室负责人
侯可勇 泰山特聘专家 博士 / 教授 / 博士生导师
侯可勇，教授，博导，泰山学者特聘专家，山东大学杰出中青年学者。主要研究方向是超高灵敏在线质谱仪器研制与大气污染物在线快速分析新方法开发。 围绕质谱核心技术创新和工程化，先后攻克了飞行时间质谱高分辨质量分析器、离子阱质谱质量分析器、高灵敏质谱化学电离源、质谱探测器、高性能射频高压电源、质谱数据分析软件等多个关键部件和核心技术的国产化； 解决了仪器可靠性、电磁兼容、环境适应性、软件智能化等工程技术难题，实现了系列高可靠关键部件模块和质谱整机的工程化。
先后承担国家重大仪器研制专项课题2项、重点研发计划课题3项、863项目1项、国家自然科学基金项目5项，承担国家重大工程“两机专项”任务等多项军民融合项目。 已获得56项发明专利授权，发表SCI论文100余篇。成果荣获创新创业二等奖1项，科技进步一等奖1项。 担任中国仪器仪表学会质谱专业委员会委员，山东省质谱学会副主任委员。
2019.11 - 至今：山东大学环境研究院，教授
2016.06 - 2019.11：中科院大连化学物理研究所，研究员
2011.10 - 2016.06：中科院大连化学物理研究所，副研究员
2009.10 - 2011.04：Purdue University，R. Graham Cooks 课题组，博士后
2008.01 - 2009.10：中科院大连化学物理研究所，助理研究员
2002.09 - 2008.01：中国科学院大连化学物理研究所，分析化学，博士
1998.07 - 2002.07：青岛大学，化学，学士
- 挥发性有机物(VOCs)在线监测及其二次污染生成机理研究
- 大气自由基探测质谱新技术及新方法研究
- 气溶胶在线检测质谱新技术及分析新方法研究
- 质谱微型化技术及其在国家安全领域的应用研究
1. 军民融合（2023-SSSD-QT00-50002），2023.9-2025.12
2. 军民融合（XM2023FH3103-WX），2024.1-2025.12
3. 国家自然科学基金面上项目（22374090），2024.1-2027.12
4. 国家自然科学基金面上项目（21874134）， 2019.1-2022.12
5. 国家自然科学基金面上项目（21675155），2017.1-2020.12
6. 国家自然科学基金面上项目（21375129），2014.1-2017.12
7. 国家自然科学基金青年基金（20907052），2010.1-2012.12
8. 国家重点研发计划课题（2022YFC3700203），2022.10-2026.9
9. 国家重大仪器专项课题（2020YFF01014503）， 2020.11-2023.10
10.国家重大研究计划子课题（2016YFC0800902），2016.7-2019.6
11.国家重大仪器专项课题（2013YQ09070302），2013.10-2016.9
12.863资环领域子课题（2014AA06A501），2014.1.1-2017.12.30
13.国家支撑计划项目子课题（2013BAK14B04），2013.1-2015.12
14.青岛市科技局重点项目（23-2-1-206-zyyd-jch），2023.7–2025.6
15.济南市“高校20条”项目（2021GXRC058）， 2022.1-2025.12
16.大连市科技局重点基金（2015A11GX031）， 2016.1-2017.12
1. Shuangying Tian†, Longxin Li†, Yingzhe Guo†, Xiuting Yang, Jianhua GuHui Lin，Yanzhen Wang, Yuan Bian*, , Feng Xu* and Yuguo Chen*, Early detection of critical illnesses using exhaled aldehydes: a non-invasive breath analysis approach, Critical Care (2025) 29:416. [DOI]
2. Yingzhe Guo; Cuiping Li; Baoqiang Li; Ruidong Liu; Zhongyao Zhang; Haijie Wang; Lin Zhang*; , Photoionization induced chemical ionization time-of-flight mass spectrometry for rapid and sensitive detection of trace gaseous chemical warfare agents, Journal of Chromatography A, 2025, 1761, 466338. [DOI]
3. Zhenming Wang, Jianwei Yang, Yingzhe Guo, Ruidong Liu, Jing Li, Weiqiang Tan*, and , Photothermal-Enhanced Desorption and Internally Heated Photochemical Ionization TOF-MS for Rapid and Quantitative Analysis of Particulate PAH Composition, Analytical Chemistry, 2025, 97, 13646−13654. [DOI]
4. Yun Wu, Mei Li*, Ruidong Liu, Jing Li, Yingzhe Guo, Dong Yang, Wei Xu*, , Photothermal Desorption and Reagent-Assisted Low-Temperature Plasma Ionization Miniature IT-MS/MS for On-Site Analysis of Illicit Drugs in Saliva and Urine, Analytical Chemistry, 2025, 97, 2081-2087. [DOI]
5. Yingzhe Guo, Ruidong Liu, Mei Li, Jing Li, Xinfeng Wang, Likun Xue, , Pollution investigation of wintertime VOCs in the coastal atmosphere of the Yellow Sea: Insights from on-line photoionization-induced CI-TOFMS, Science of The Total Environment, 2024, 177568. [DOI]
6. Guo, Yingzhe; Liu, Ruidong; Li, Mei; Li, Jing; Yang, Dong; Wang, Zhenming; , Rapid Detection of Trace Organic Amines in Seawater: An Innovative Approach Using Photoelectron-Induced Chemical Ionization TOFMS with Online Derivatization and Dynamic Purging-Release Techniques, Analytical Chemistry, 2024, 96, 15746-15753. [DOI]
7. Yonglei Zhang, Ruidong Liu, Mei Li*, Yingzhe Guo, Jichuang Kong, , A dopant-assisted iodide-adduct chemical ionization time-of-flight mass spectrometer based on VUV lamp photoionization for atmospheric low-molecular-weight organic acids analysis, Journal of Environmental Sciences, 2025, 149, 500-511. [DOI]
8. Xinbo Wang*, Pengcheng Ma, YuanJu Jing, Cong Yu, Hao Qiu, Chun Kang, Zhaojie Cui, , Alex C.K. Yip, Ben Hang Yin*, A Soluble and Recyclable Polymeric Adsorbent of Intrinsic Microporosity for CO2 Capture, Materials Today Sustainability, 2023, 24, 100484. [DOI]
9. Jing Li, Mei Li*, Ruidong Liu, Yingzhe Guo, Dong Yang, , A Homogeneous Sampling Membrane Inlet Photoelectron Ionization Miniature Time-of-Flight Mass Spectrometer for on-Line Determination of Ethane, Talanta, 2024, 267, 125221. [DOI]
10. Yonglei Zhang, Ruidong Liu, Dong Yang, Yingzhe Guo, Mei Li*, , Chemical ionization mass spectrometry: Developments and applications for on-line characterization of atmospheric aerosols and trace gases, Trends Anal. Chem., 2023, 168, 117353. [DOI]
11. Ruidong Liu, Yingzhe Guo, Mei Li*, Jing Li, Dong Yang, , Development and Application of a Chemical Ionization Focusing Integrated Ionization Source TOFMS for Online Detection of OVOCs in the Atmosphere, Molecules, 2023, 28 (18), 6600. [DOI]
12. Wang Xinbo, Qiu Hao, Yu Cong, Jing YuanJu, Kang Chun, Qin Xin; , Cui Zhaojie, Yin Benhang, Shan Bin, Solution-reprocessable polymers of intrinsic microporosity as adsorbents for carbon dioxide capture, Separation and Purification Technology, 2023, 315, 123723.
13. Zhiyi Liu, Min Li, Xinfeng Wang, Yiheng Liang, Yueru Jiang, Jing Chen, Jiangshan Mu, Yujiao Zhu, He Meng, Lingxiao Yang, , Yifeng Wang, Likun Xue, Large contributions of anthropogenic sources to amines in fine particles at a coastal area in northern China in winter, Science of the Total Environment, 2022, 839: 156281.
14. Min Dang, Mei Li, Jing Li, Ruidong Liu, Yingzhe Guo, , Emissions of Formamide and Ammonia from Foam Mats: Online Measurement Based on Dopant-Assisted Photoionization TOFMS and Assessment of Their Exposure for Children, Environ. Sci. Technol., 2023, 57, 5646-5654. [DOI]
15. Mei Li, Bing Liu, Taotao Chen, Ruidong Liu, Yingzhe Guo, , On-site leakage locating of underground natural gas pipeline based on Ne tracer by miniature time-of-flight mass spectrometry, Talanta, 2023, 254, 124170.
16. Bing Liu, Wenxi Tang, Hang Li, Ruidong Liu, Fengshuo Dong, Yingzhe Guo, Jianjun Li and , Point-of-care detection of sevoflurane anesthetics in exhaled breath using miniature TOFMS for diagnosis of postoperative agitation symptoms in children, Analyst, 2022, 147, 2484 - 2493.
17. Fengshuo Dong, Hang Li, Bing Liu, Ruidong Liu, , Protonated acetone ion chemical ionization time-of-flight mass spectrometry for real-time measurement of atmospheric ammonia, Journal of Environmental Sciences, 2022, 114, 66-74. [DOI]
18. Min Dang, Ruidong Liu, Fengshuo Dong, Bing Liu, , Vacuum ultraviolet photoionization on-line mass spectrometry: instrumentation developments and applications, Trends in Analytical Chemistry, 2022, 149, 116542.
19. 刘兵，董丰硕，刘瑞东，，真空紫外光电离质谱技术进展及其在快速分析中的应用，分析测试学报，2021, 40(2), 208-214.
20. Chenxin Wu, Yuxuan Wen, Hua Lei, Jichun Jiang, Yuanyuan Xie, Yixue Cao, Shuo Chai, , and Haiyang Li*, Rapid and highly sensitive measurement of trimethylamine in seawater using dynamic purge-release and dopant-assisted atmospheric pressure photoionization mass spectrometry, Analytica Chimica Acta, 2020, 1137, 56-63.
21. Weimin Wang, Chuting Xu, Huiwen Ruan, Hong Li, Yuming Xing, , Haiyang Li, Solvent assisted thermal desorption for on-site detection of illegal drugs by miniature ion trap mass spectrometer, Analytical Methods, 2020, 12(3), 264-271.
22. Chuting Xu, Weiming Wang, Shuang Wang, , Haiyang Li*, Potential analytical methods for on-site oral drug test: Recent developments and applications, Trends in Analytical Chemistry, 2019, 120, 115649.
23. Weimin Wang, Shuang Wang, Chuting Xu, Hong Li, Yuming Xing, , Haiyang Li*, Rapid Screening of Trace Volatile and Nonvolatile Illegal Drugs by Miniature Ion Trap Mass Spectrometry: Synchronized Flash-Thermal-Desorption Purging and Ion Injection, Anal. Chem., 2019, 91(15), 10212-10220.
24. Shuang Wang, Weimin Wang, Hong Li, Yuming Xing, , and Haiyang Li*, Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer, Anal. Chem., 2019, 91(6), 3845-3851. DOI: 10.1021/acs.analchem.8b04168
25. QingYun Li, Lei Hua, Yuanyuan Xie, Jichun Jiang, Hanwei Li, Keyong Hou, Di Tian* and HaiYang Li*, Single photon ionization time-of-flight mass spectrometry with a windowless RF-discharge lamp for high temporal resolution monitoring of the initial stage of methanol-to-olefins reaction, Analyst, 2019, 144(4): 1104-1109. DOI: 10.1039/C8AN01840E
26. Chenxin Wu, Wei Liu, Jichun Jiang, Yan Wang, , and Haiyang Li*, An in-source helical membrane inlet single photon ionization time of flight mass spectrometer for automatic monitoring of trace VOCs in water at minutes resolution, Talanta, 2019, 192, 46-51.
27. Yan Wang, Lei Hua, Qingyun Li, Jichun Jiang, Keyong Hou, Chenxin Wu, and Haiyang Li, Direct Detection of Small n-Alkanes at Sub-ppbv Level by Photoelectron-Induced O2+ Cation Chemical Ionization Mass Spectrometry at kPa Pressure, Anal. Chem., 2018, 90 (8), 5398–5404.
28. Yan Wang, Lei Hua, Jichun Jiang, Yuanyuan Xie, Keyong Hou, Qingyun Li, Chenxin Wu and Haiyang Li, High-pressure photon ionization time-of-flight mass spectrometry combined with dynamic purge-injection for rapid analysis of volatile metabolites in urine, Analytica Chimica Acta, 2018, 1008, 74-81.
29. Shuang Wang, Zhe Wang, , Haiyang Li*, Thermal Desorption Low Temperature Plasma Ionization Mass Spectrometry for Rapid and Sensitive Detection of Pesticides in Broomcorn, Chinese Journal of Analytical Chemistry, 2017, 45(2): 175-182.
30. Zhou Lijuan, Jiang Jichun, Zhao Kun, Li Jinxu, Wu Chenxin, Li Haiyang, Tian Di*, , Radiofrequency field enhanced chemical ionization with vacuum ultraviolet lamp for miniature time-of-flight mass spectrometer, Chinese Chemical Letters, 2018, 29(5), 707-710.
31. , Li J, Qu T, et al., Development of a suitcase time-of-flight mass spectrometer for in situ fault diagnosis of SF6‐insulated switchgear by detection of decomposition products, Rapid Commun. Mass Spectrom., 2016, 30(S1): 38-43.
32. Liu W, Jiang J, , Weiguo Wang, Yachen Qi, Yan Wang, Yuanyuan Xie, Lei Hua, Haiyang Li*, Online monitoring of trace chlorinated benzenes in flue gas of municipal solid waste incinerator by windowless VUV lamp single photon ionization TOFMS coupled with automatic enrichment system, Talanta, 2016, 161: 693-699.
33. Wang Yan, Jiang Jichun, Hua Lei, , Yuanyuan Xie, Ping Chen, Wei Liu, Qingyun Li, Shuang Wang, and Haiyang Li, High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis, Anal. Chem., 2016, 88(18): 9047-9055.
34. Jichun Jiang, Yan Wang, , Lei Hua, Ping Chen, Wei Liu , Yuanyuan Xie, Haiyang Li, Photoionization-Generated Dibromomethane Cation Chemical Ionization Source for Time-of-Flight Mass Spectrometry and Its Application on Sensitive Detection of Volatile Sulfur Compounds, Anal. Chem., 2016, 88, 5028–5032.
35. Wendong Chen, , Lei Hua, Haiyang Li, Dopant-assisted reactive low temperature plasma probe for sensitive and specific detection of explosives, Analyst, 2015, 140(17): 6025-6030. DOI: 10.1039/C5AN00816F
36. Lei Hua,, Ping Chen, Yuanyuan Xie, Jichun Jiang, Yan Wang, Weiguo Wang, and Haiyang Li, Realization of In-Source Collision-Induced Dissociation in Single-Photon Ionization Time-of-Flight Mass Spectrometry and Its Application for Differentiation of Isobaric Compounds, Anal. Chem., 2015, 87 (4), 2427–2433.
37. Chuang Chen, , Weiguo Wang, Jinghua Li, Haiyang Li, Ambient temperature nanoelectrospray ion mobility detector for high performance liquid chromatography in determining amines, J. Chromatogr. A, 2014, 1358, 192-198.
38. Yuanyuan Xie, Lei Hua,, Ping Chen, Wuduo Zhao, Wendong Chen, Bangyu Ju, and Haiyang Li, Long-Term Real-Time Monitoring Catalytic Synthesis of Ammonia in a Microreactor by VUV-Lamp-Based Charge-Transfer Ionization Time-of-Flight Mass Spectrometry, Anal. Chem., 2014, 86 (15), 7681–7687. DOI: 10.1021/ac501576f
39. Wendong Chen, , Lei Hua, Xingchuang Xiong, Haiyang Li, Water-assisted low temperature plasma ionization source for sensitive detection of explosives, RSC Advances, 2014, 28, 4, 14791-14794. DOI: 10.1039/C4RA00683F
40. Ping Chen, , Lei Hua, Yuanyuan Xie, Wuduo Zhao, Wendong Chen, Chuang Chen, and Haiyang Li, Quasi-Trapping Chemical Ionization Source Based on a Commercial VUV Lamp for Time-of-Flight Mass Spectrometry, Anal. Chem., 2014, 86 (3), 1332–1336.
41. Shasha Cheng, Weiguo Wang, Qinghua Zhou, Chuang Chen, Liying Peng, Lei Hua, Yang Li, , and Haiyang Li, Fast Switching of CO3–(H2O)n and O2–(H2O)n Reactant Ions in Dopant-Assisted Negative Photoionization Ion Mobility Spectrometry for Explosives Detection, Anal. Chem., 2014, 86, 2687-2693. DOI: 10.1021/ac404067z
42. , Fanglong Li, Wendong Chen, Ping Chen, Yuanyuan Xie, Wuduo Zhao, Lei Hua, Kemei Pei, Haiyang Li*, An In-Source Stretched Membrane Inlet for On-Line Analysis of VOCs in Water with Single Photon Ionization TOFMS, Analyst, 2013, 138(17): 5826-5831. doi:10.1039/C3AN00659J
43. Chen W, , Xiong X, Jiang Y, Zhao W, Hua L, Chen P, Xie Y, Wang Z, Li H*. Non-contact halogen lamp heating assisted LTP ionization miniature rectilinear ion trap: a platform for rapid, on-site explosives analysis, Analyst, 2013, 138(17): 5068-73. doi: 10.1039/c3an00555k
44. Shasha Cheng, Jian Dou, Weiguo Wang, Chuang Chen, Lei Hua, Qinghua Zhou, , Jinghua Li, and Haiyang Li*, Dopant-Assisted Negative Photoionization Ion Mobility Spectrometry for Sensitive Detection of Explosives, Anal. Chem., 2013, 85, 319−326.
45. Xixi Liang, Qinghua Zhou, Weiguo Wang, Xin Wang, Wendong Chen, Chuang Chen, Yang Li, , Jinghua Li, and Haiyang Li, Sensitive Detection of Black Powder by a Stand-Alone Ion Mobility Spectrometer with an Embedded Titration Region, Anal. Chem., 2013, 85, 4849−4852.
46. Qinghao Wu, Lei Hua, , Huapeng Cui, Haiyang Li, Vacuum Ultraviolet Lamp Based Magnetic Field Enhanced Photoelectron Ionization and Single Photon Ionization Source for Online Time-of-Flight Mass Spectrometry, Anal. Chem., 2011, Vol 83, 8992-8998.
47. , Wei Xu, R. Graham Cooks, Zheng Ouyang, Sampling Wand for an Ion Trap Mass Spectrometer, Anal. Chem., 2011, Vol 83 (5), 1857-1861.
48. Lei Hua, Qinghao Wu, , Huapeng Cui, Ping Chen, Weiguo Wang, Jinghua Li, Haiyang Li*, Single Photon Ionization and Chemical Ionization Combined Ion Source Based on a Vacuum Ultraviolet Lamp for Orthogonal Acceleration Time-of-Flight Mass Spectrometry, Anal. Chem., 2011, 83(13): 5309-5316.
1. 侯可勇，刘瑞东，董丰硕，海水中有机胺实时质谱分析的膜富集喷雾电离装置和方法，CN113237944B
2. 侯可勇，刘瑞东，刘兵，一种直线式同轴反射便携飞行时间质谱及其应用，CN113594020B
3. 侯可勇，董丰硕，刘瑞东，一种不同湿度大气中氨气的化学电离质谱分析系统和方法，CN113138225A
4. 侯可勇，刘瑞东，厉梅，用于大气中乙二醛实时在线检测质谱的光化学电离装置，CN115332045A
5. 侯可勇，刘瑞东，厉梅，一种气压控制的光电子电离和化学电离切换系统及方法，CN117174567A
6. 侯可勇，刘兵，刘瑞东，即时检测七氟烷的便携式质谱装置和方法，CN113671014A
7. 侯可勇，张永磊，刘瑞东，一种不同湿度下大气中有机酸的在线准确定量光致化学电离质谱系统和方法，CN116879381A
8. 侯可勇，孔纪创，刘瑞东，一种气态亚硝酸的制备方法及发生系统，2024100392336
9. 侯可勇，李静，厉梅，刘瑞东，实现气体高灵敏质谱分析的大流量膜进样装置及使用方法，202310827976.5
10. 侯可勇，韩笑笑，李海洋，李金旭，蒋吉春，VOCs原位冷阱富集-热解析样品前处理装置，201711252056.6
11. 侯可勇，吴称心，谢园园，于艺，李海洋，一种源内膜进样射频增强化学电离源，201911225130.4
12. 侯可勇，王伟民，王爽，李海洋，一种屏蔽光电子对光电离离子源污染的新方法，201711203498.1
13. 侯可勇，王伟民，王爽，李海洋，一种利用空气动力学辅助的方法提高离子传输效率的装置，201711204823.6
14. 侯可勇，王爽，李海洋，仓怀文，李东明，王伟民，一种离子迁移谱和离子阱质谱联用电离腔体，201611013527.3
15. 侯可勇，李静，陈爽，王林森，一种航空发动机燃烧室出口燃气成分在线检测质谱电离源，202411705688.3
16. 侯可勇，吴云，厉梅，一种在线质谱大气压化学电离源及其应用，202211115743.4
17. 侯可勇，郑天赐，一种大气挥发性有机污染物溯源无人机离子阱质谱系统及其应用方法，2024116378841
18. 侯可勇，李海洋，“一种在线气体分析质谱中的膜进样样品富集装置”，发明专利，专利号：200710011223.8
19. 侯可勇，李海洋，“微型飞行时间质谱在线样品富集装置”，发明专利，专利号：200610134947.7
20. 侯可勇，董璨，李海洋，“飞行时间质谱仪中真空紫外灯电离装置”，发明专利，专利号：200610011793.2
21. 侯可勇，吴庆浩，崔华鹏，花磊，李海洋， “微型质谱仪中空心阴极放电真空紫外光电离源”，发明专利，专利号：2009102654451
22. 侯可勇，陈文东，李海洋，“一种添加选择性检测试剂的介质阻挡放电质谱电离源装置”，专利号：201210536370.8
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